Our ECS includes two primary cell cannabinoid receptors, CB1 and CB2. While these receptors are found throughout the body, they tend to concentrate in certain areas. CB1 receptors are abundant in the brain, while CB2 receptors are more often found on immune cells, in the gastrointestinal tract, and in the peripheral nervous system.
The endocannabinoid Anandamide, as well the phytocannabinoid THC target CB1 receptors, predominantly found in the brain and nervous system, as well as in peripheral organs and tissues. The other main endocannabinoid 2-Arachidonoylglycerol (2-AG) and its own mimetic phytocannabinoid, CBD, are active at both CB1 and CB2 cannabinoid receptors.